Sunday, November 21, 2010

Mesothelioma

Mesothelioma Awareness Editorial Reviews

From The New England Journal of Medicine

Mesothelioma is a multiauthored book that aims to provide a comprehensive overview of the epidemiology, biology, diagnosis, and treatment of Malignant pleural mesothelioma. Edited by Drs. Bruce Robinson and Philippe Chahinian (from Perth, Australia, and New York City, respectively), the book brings together an international group of authors, most of whom are acknowledged experts on this disease.

The selection of authors highlights the fact that mesothelioma, though an uncommon disease in many countries, is a considerable problem internationally. The strongest focus of the book is on the epidemiology of malignant pleural mesothelioma. Of the 20 chapters, 7 discuss the epidemiology and history of the disease in North America, Europe, Australia, South Africa, and Japan.

One of these chapters chronicles how its author, Christopher Wagner, now deceased, and his colleagues established the link between exposure to asbestos and mesothelioma in South Africa circa 1960, despite initial skepticism from physicians elsewhere.

Chapters devoted to the pathology of mesothelioma and to staging and surgery, gene therapy, photodynamic therapy, molecular pathogenesis (including the role of simian virus 40), and immunotherapy are well written, generally accurate, and thorough. A chapter on the medicolegal aspects of mesothelioma is a useful and highly relevant part of the book in the light of the large volume of litigation concerning asbestos that is related to mesothelioma.

In contrast, chapters on clinical and palliative care and on imaging are not so well organized and lack detail. More attention could have been given to descriptions of the clinical and radiologic presentation according to disease stage, and the discussion of the comparative merits of computed tomographic and magnetic resonance imaging could have been enhanced with additional illustrations.

The discussion of palliative care is cursory and would have benefited from an expert discussion of the methods of pain management. Although the role of pleuroscopy is addressed in a chapter by C. Boutin, a leader in this technique, current clinical practice in North America does not parallel this European experience, and some comment in that regard would have been beneficial. Radiation therapy and chemotherapy are grouped together in a single chapter written by Chahinian, a medical oncologist. A full chapter on radiation techniques and results written by a radiation oncologist would have been worthwhile. Finally, the organization of the chapters is puzzling.

Chapters on epidemiology are placed at both the beginning and the end of the book, and the progression of the chapters in between is not entirely logical. As is true of all textbooks, this book is not absolutely current because of the inherent delay between the writing of the individual chapters and publication. Although a decade ago this delay would not have made a difference for a book dealing with mesothelioma, today it does.

Advances in biology and clinical care are now occurring at a rapid pace in this disease, and therefore some of the information presented is subtly out of date. Overall, however, this book provides an excellent review for the practicing clinician. There are few textbooks addressing mesothelioma, and this one is a welcome addition to the literature. Valerie W. Rusch, M.D.

Copyright © 2004 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine is a registered trademark of the MMS.


Review

Exhaustive and clearly written. - Annals of Oncology

This book should be of interest to those taking care of patients with mesothelioma, and would make a good addition to the library of professionals concerned with occupational lung disease. - CHEST

Product Description

(Martin Dunitz) Second author is with Mount Sinai Hospital, New York, NY. Presents a state-of-the-art review of this condition, from laboratory to the bedside, from diagnostic procedures through treatment, and from imaging and early detection to medico-legal issues. For clinicians and scientists and members of the legal profession.


Learn more here...

Mesothelioma [Hardcover]

Malignant Mesothelioma: Pathogenesis, Diagnosis, and Translational Therapies

Malignant mesothelioma is a rare form of cancer in which the cancer cells are found in the sac lining the chest (pleura) or abdomen (peritoneum).

This lethal disease is associated with asbestos and has vast economic and legal implications. As the disease takes approximately twenty years to manifest itself in humans, a wave of diagnoses are expected in the near future.

In the United States alone, an estimated 3,500 - 4,000 patients are diagnosed with mesothelioma annually, and it is estimated that over the next 35 years, more than 250,000 people in Western Europe will be diagnosed with the disease.

Malignant Mesothelioma, edited by internationally recognized experts in the field, is a comprehensive text that relates science, pathology, clinical aspects and therapy for mesothelioma under one cover. The book integrates the newest research and advances in its discussions of the disease, covering such topics as carcinogenesis, epidemiology, benchwork, endoscopy, multimodality approaches and treatment.

It includes discussions on novel approaches to mesothelioma, such as gene therapy, vaccination strategies and immunotherapy, as well as discussions on the legal and economic aspects of the disease.

Over 200 illustrations round out the text. An invaluable reference for the medical oncologist, thoracic surgeon, radiation oncologist, pulmonologist, and benchworker interested in the disease.

Review

From the reviews:

"Malignant Mesothelioma is an uncommon neoplasm usually associated with exposure to asbestos. … Harvey Pass and colleagues have edited an up-to-date, comprehensive book that includes a wide range of information, from a historical perspective to descriptions of the latest treatment. … Laboratory researchers will use it as a resource for information … of mesothelioma. … Clinicians will benefit from this complete guide ... . I highly recommend this book to all those who are interested in mesothelioma." (Julie R. Brahmer, The New England Journal of Medicine, March, 2006)

"This is a reference book suitable for departmental and medical libraries and for the shelves of those who have a particular clinical or research interest in mesothelioma … . Pass, Vogelzang and Carbone envisioned a comprehensive text and have achieved it. … To be useful such a book must be well indexed; and this is. The individual chapters are well referenced … . The text is well edited … . This is a quality production. … Overall it is highly recommended." (Michael Byrne, CancerForum, Vol. 30 (3), November, 2006)


Learn more...



Malignant Mesothelioma: Pathogenesis, Diagnosis, and Translational Therapies [Hardcover]

Saturday, November 20, 2010

They Said Months. I Chose Years! A Mesothelioma Survivor's Story

Editorial Reviews

Product Description

In October 2001, James O'Connor was diagnosed with mesothelioma, the asbestos caused cancer. His prognosis was less than a year to live. Surgery was not possible because of the position of the tumor and chemotherapy would decrease his quality of life and not significantly improve his length of life. His oncologist suggested that he take his wife on a cruise and start hospice care upon his return.

James rejected the idea. Instead he was determined to survive this cancer. Working with other professional clinicians, he formulated a regimen of over 100 supplements a day, changed his diet, practiced mind-body medicine, and relied on his own discipline to see him through the difficult times ahead.

More than six years later, James is alive and active. He enjoys his life and continues his holistic regimen every day.


About the Author

In They Said Months, I Chose Years: A Mesothelioma Survivors Story, author and cancer survivor James OConnor explains what he did to survive his diagnosis of mesothelioma and provides much of the science behind his decisions. He cites nearly one hundred medical articles that support the paradigm of using nutrition to help manage a chronic disease like cancer. This inspirational book reminds us that there may be other ways to beat cancer beyond chemotherapy, radiation and surgery. It also prompts us to recall the wisdom of Hippocrates, the father of medicine. Over 2,000 years ago this Greek physician said, Let food be thy medicine and medicine be thy food.


Learn more...

Mesothelioma Awareness Ribbon Round Mouse Pad

Beating Mesothelioma Together Long Sleeve T-shirt